Job Description

Scientist I, New Discovery & Platform

W2 Contract-to-Hire

Salary Range: $135,200 - $145,600 per year

Location: Redwood City, CA - Onsite Role

Job Summary:

We are seeking a curious and dedicated Scientist to join the New Discovery & Platform team within Discovery Sciences. The successful candidate will support early-stage discovery efforts to interrogate new targets, deploy current oncology assay technologies, and develop new technology platforms to advance drug discovery. This primarily lab-focused role will contribute at the bench by developing lysate-based assays, supporting pooled screening, and advancing new assay platforms. In addition to strong experimental skills, we seek a scientist who bridges chemistry and biology, with a track record of creative, innovative assay development to expand our discovery capabilities.

Duties and Responsibilities:

• Develop and apply methods for screening protein-protein interactions (e.g., MSD, BLI) to assess target engagement in physiologically relevant contexts.
• Apply and expand biochemical and biophysical assay platforms, including TR-FRET, fluorescence polarization (FP), surface plasmon resonance (SPR), biolayer interferometry (BLI), and mass spectrometry.
• Design, develop, and execute pooled screening experiments (e.g., DEL, display technologies such as mRNA or yeast display).
• Perform chemical or protein conjugation/labeling to support assay development, target characterization, and platform innovation.
• Interrogate new therapeutic targets while deploying current oncology assay technologies and contributing to new technology development.
• Optimize, troubleshoot, and analyze assays to support early-stage discovery projects.
• Collaborate closely with internal partners to integrate experimental outcomes into broader discovery strategies.
• Maintain accurate, timely, and detailed documentation of experiments and findings.
• Support automation workflows and contribute to data analysis pipelines for high-throughput studies.

Requirements and Qualifications:

• PhD in Chemical Biology, Biochemistry, Biophysics, or related field (0-3 years of relevant industry or postdoctoral experience).
• Evidence of bridging chemistry and biology, with a demonstrated track record of innovative assay development.
• Strong foundation in biochemical and biophysical methods for protein-ligand interactions, protein-protein interactions, and enzymatic activity measurement.
• Hands-on experience with target engagement assays, TR-FRET, FP, SPR, BLI, mass spectrometry, pooled screening approaches (e.g., DEL, mRNA display, yeast display), and/or chemical/protein conjugation or labeling.
• Proficiency in data analysis, statistical interpretation, and experimental design.
• Demonstrated ability to excel in a primarily lab-focused environment with precision and attention to detail.
• Excellent problem-solving skills, adaptability, and a collaborative mindset.

Preferred Qualifications:

• Familiarity with laboratory automation systems and high-throughput workflows.
• Experience with large dataset handling and visualization tools (e.g., Genedata, Spotfire, KNIME, Vortex).
• Detail-oriented with the ability to manage multiple priorities in a dynamic setting.

Desired Skills and Experience

Chemical Biology, Biochemistry, Biophysics, assay development, MSD, BLI, TR-FRET, fluorescence polarization, surface plasmon resonance, biolayer interferometry, mass spectrometry, DEL, mRNA, data analysis, aboratory automation systems, Genedata, Spotfire, KNIME, Vortex

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.

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